Sympathoadrenal Hyperplasia Causes Renal Malformations in RetMEN2B-Transgenic Mice

The tyrosine kinase receptor Ret is expressed in the ureteric bud and is required for normal renal development. Constitutive loss of Ret, its co-receptor gfrα-1, or the ligand glial cell line-derived neurotrophic factor results in renal agenesis. Transgenic embryos that express a constitutively active form of Ret (RetMEN2B) under the control of the dopamine-β-hydroxylase (DβH) promoter develop profound neuroglial hyperplasia of their sympathetic...