A randomised, placebo‐controlled trial comparing the effects of tapentadol and oxycodone on gastrointestinal and colonic transit in healthy humans

Tapentadol is a mu-opioid receptor agonist and norepinephrine reuptake inhibitor. In clinical trials, tapentadol provided somatic pain relief comparable to mu-opioids such as oxycodone, with significantly less gastrointestinal adverse effects. The acute effects of tapentadol on gastrointestinal and colonic transit are unclear.To compare acute effects of oral tapentadol and oxycodone on gastric, small bowel and colonic transit of solids in 38...