Associations of MDM2 SNP309, Transcriptional Activity, mRNA Expression, and Survival in Stage I Non-Small-Cell Lung Cancer Patients with Wild-Type p53 Tumors

Published on Apr 1, 2010in Annals of Surgical Oncology4.061
· DOI :10.1245/S10434-009-0853-2
Wen Pin Chien6
Estimated H-index: 6
(CSMU: Chung Shan Medical University),
Ruey-Hong Wong25
Estimated H-index: 25
(CSMU: Chung Shan Medical University)
+ 2 AuthorsHuei Lee50
Estimated H-index: 50
(CSMU: Chung Shan Medical University)
Sources
Abstract
Background Mouse double minute 2 (MDM2) is a negative regulator of p53. In the present study, we examined MDM2 transcriptional activity and messenger RNA (mRNA) expression in lung tumors with respect to MDM2 SNP309 genotypes and p53 mutation status, and the effects of MDM2 SNP309 genotypes and p53 mutation status on lung cancer prognosis.
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