Preparation and characterization of various solid dispersion formulations of itraconazole to enhance the drug dissolution profile

This study investigated various solid dispersions of itraconazole with different carrier blends to enhance its dissolution. HPMC E5, HPMC E15, PEG 20000 and TPGS 1000 were used to construct 20 % drug containing solid matrices by spray drying method. The formulations were analyzed in terms of dissolution profile, x-ray diffraction (XRD) and/or differential scanning calorimetry (DSC) pattern once immediately after preparation and again after...