A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.

Volume: 9, Issue: 3
Published: Mar 21, 2013
Abstract
The CDKN1B gene encodes the cyclin-dependent kinase inhibitor p27KIP1, an atypical tumor suppressor playing a key role in cell cycle regulation, cell proliferation, and differentiation. Impaired p27KIP1 expression and/or localization are often observed in tumor cells, further confirming its central role in regulating the cell cycle. Recently, germline mutations in CDKN1B have been associated with the inherited multiple endocrine neoplasia...
Paper Details
Title
A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype.
Published Date
Mar 21, 2013
Volume
9
Issue
3
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