Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation

Objective Macrophages are key players in the pathogenesis of rheumatoid synovitis as well as in atherosclerosis. To determine whether atherogenic oxidized phospholipids potentially contribute to synovial inflammation and subsequent monocyte/macrophage recruitment, we examined the effects of oxidized 1‐ palmitoyl‐2‐arachidonoyl‐ sn ‐3‐glycero‐phosphorylcholine (OxPAPC) on chemokine expression and leukocyte recruitment in a facsimile synovium in...