Evaluation of the Usefulness of Breast Cancer Resistance Protein (BCRP) Knockout Mice and BCRP Inhibitor-Treated Monkeys to Estimate the Clinical Impact of BCRP Modulation on the Pharmacokinetics of BCRP Substrates

Published on May 1, 2015in Pharmaceutical Research3.242
· DOI :10.1007/S11095-014-1563-4
Tsuyoshi Karibe4
Estimated H-index: 4
(Daiichi Sankyo),
Rie Hagihara-Nakagomi1
Estimated H-index: 1
(Daiichi Sankyo)
+ 7 AuthorsTakashi Izumi17
Estimated H-index: 17
(Daiichi Sankyo)
Purpose To evaluate whether the impact of functional modulation of the breast cancer resistance protein (BCRP, ABCG2 421C>A) on human pharmacokinetics after oral administration is predictable using Bcrp knockout mice and cynomolgus monkeys pretreated with a BCRP inhibitor, elacridar.
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