The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells
Abstract
Intestinal regulatory T cells (Treg cells) are necessary for the suppression of excessive immune responses to commensal bacteria. However, the molecular machinery that controls the homeostasis of intestinal Treg cells has remained largely unknown. Here we report that colonization of germ-free mice with gut microbiota upregulated expression of the DNA-methylation adaptor Uhrf1 in Treg cells. Mice with T cell-specific deficiency in Uhrf1...
Paper Details
Title
The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells
Published Date
Apr 28, 2014
Journal
Volume
15
Issue
6
Pages
571 - 579
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