Trial watch
Abstract
Cardiac glycosides (CGs) are natural compounds sharing the ability to operate as potent inhibitors of the plasma membrane Na+/K+-ATPase, hence promoting—via an indirect mechanism—the intracellular accumulation of Ca2+ ions. In cardiomyocytes, increased intracellular Ca2+ concentrations exert prominent positive inotropic effects, that is, they increase myocardial contractility. Owing to this feature, two CGs, namely digoxin and digitoxin, have...
Paper Details
Title
Trial watch
Published Date
Feb 1, 2013
Journal
Volume
2
Issue
2
Pages
e23082 - e23082
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Notes
History