Both systolic and diastolic dysfunction characterize nonischemic inhibition of myocardial energy metabolism: An experimental strain rate echocardiographic study

Background Ischemia is primarily a metabolic event. However, regional functional changes can be affected by structural alterations. We developed an experimental model of sole myocardial energy metabolism inhibition and characterized the resulting regional dysfunction. Methods In 12 pigs, we regionally inhibited creatine kinase (CK) and, consequently, myocyte high-energy phosphate transfer by intracoronary administration of iodoacetamide....