ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.

Volume: 7, Issue: 6
Published: Jun 29, 2012
Abstract
Pathogen-activated and damage-associated molecular patterns activate the inflammasome in macrophages. We report that mouse macrophages release IL-1β while co-incubated with pro-B (Ba/F3) cells dying, as a result of IL-3 withdrawal, by apoptosis with autophagy, but not when they are co-incubated with living, apoptotic, necrotic or necrostatin-1 treated cells. NALP3-deficient macrophages display reduced IL-1β secretion, which is also inhibited in...
Paper Details
Title
ATP release from dying autophagic cells and their phagocytosis are crucial for inflammasome activation in macrophages.
Published Date
Jun 29, 2012
Journal
Volume
7
Issue
6
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.