Efficacy of Itraconazole in the Treatment of Patients with Chronic Cough Whose Sputa Yield Basidiomycetous Fungi—Fungus-Associated Chronic Cough (FACC)

Published on Jul 21, 2009in Journal of Asthma1.899
· DOI :10.1080/02770900902846331
Haruhiko Ogawa17
Estimated H-index: 17
,
Masaki Fujimura53
Estimated H-index: 53
(Kanazawa University)
+ 1 AuthorsKoichi Makimura36
Estimated H-index: 36
(Teikyo University)
Sources
Abstract
Objectives. This controlled study was performed to clarify the therapeutic benefit of itraconazole for the treatment of patients with chronic cough, wherein a sputum culture yielded basidiomycetous (BM) fungi. Methods. Of the 171 patients who visited our hospital for the diagnosis and treatment of chronic cough, BM was detected in the sputum of 39 patients. Informed consents were obtained from 21 patients who were subsequently enrolled in this trial. After the administration of the standard therapy, all the patients were enrolled in a randomized placebo-controlled study with 2 weeks of treatment with a low dose of itraconazole (50 mg/day) (n = 10) in comparison with a corresponding period of treatment with matched placebo (ambroxol hydrochloride 45 mg/day) (n = 11). Coughing was assessed using subjective cough symptom scale and capsaicin cough challenging. Results. The treatment with itraconazole, but not placebo (p = 0.17), was associated with a significant improvement in the cough scale (p = 0.0051); mo...
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