A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation
Abstract
Organophosphorus (OP) nerve agents and pesticides inhibit acetylcholinesterase (AChE), and this is thought to be a primary mechanism mediating the neurotoxicity of these compounds. However, a number of observations suggest that mechanisms other than or in addition to AChE inhibition contribute to OP neurotoxicity. There is significant experimental evidence that acute OP intoxication elicits a robust inflammatory response, and emerging evidence...
Paper Details
Title
A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation
Published Date
Jun 1, 2012
Journal
Volume
33
Issue
3
Pages
575 - 584
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