Development of Corpus Callosum in Preterm Infants Is Affected by the Prematurity: In Vivo Assessment of Diffusion Tensor Imaging at Term-Equivalent Age

Published on Mar 1, 2011in Pediatric Research2.747
· DOI :10.1203/PDR.0B013E3182084E54
Tatsuji Hasegawa7
Estimated H-index: 7
(Kyoto Prefectural University of Medicine),
Kei Yamada1
Estimated H-index: 1
(Kyoto Prefectural University of Medicine)
+ 9 AuthorsHajime Hosoi33
Estimated H-index: 33
(Kyoto Prefectural University of Medicine)
Sources
Abstract
Callosal injury in preterm infants is a key factor affecting neurodevelopmental outcome. We investigated the charac- teristics of corpus callosum (CC) in preterm infants without apparent white matter lesions. We studied 58 preterm infants divided into three groups of 23-25, 26 -29, and 30 -33 wk GA. Diffusion tensor imag- ing (DTI) was obtained at term-equivalent age. The CC was parcel- lated into the genu, body, isthmus, and splenium. We measured fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of each CC subdivision using tractography and manual region of interest analysis. The cross-sectional areas were also measured. At the isthmus and splenium in the 23-25 GA group, the FA was significantly lower and the size was also significantly reduced. Furthermore, the FA and cross-sectional areas in the posterior CC decreased linearly with decreasing GA. There were no differences in FA and cross-sectional areas in other CC subdivisions, and no differences in ADC in any CC subdivisions, among the GA groups. We demonstrated that preterm infants without apparent white matter lesions affect development of the posterior CC depending on the degree of prematurity. (Pediatr Res 69: 249-254, 2011)
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