Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.

Volume: 35, Issue: 11, Pages: 1979 - 1991
Published: Jun 1, 2015
Abstract
The Wnt coreceptors Lrp5 and Lrp6 are essential for normal postnatal bone accrual and osteoblast function. In this study, we identify a previously unrecognized skeletal function unique to Lrp5 that enables osteoblasts to oxidize fatty acids. Mice lacking the Lrp5 coreceptor specifically in osteoblasts and osteocytes exhibit the expected reductions in postnatal bone mass but also exhibit an increase in body fat with corresponding reductions in...
Paper Details
Title
Wnt-Lrp5 signaling regulates fatty acid metabolism in the osteoblast.
Published Date
Jun 1, 2015
Volume
35
Issue
11
Pages
1979 - 1991
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