Essential role of the disintegrin-like domain in ADAMTS13 function

Blood20.30
Volume: 113, Issue: 22, Pages: 5609 - 5616
Published: May 28, 2009
Abstract
ADAMTS13 is a highly specific multidomain plasma metalloprotease that regulates the multimeric size and function of von Willebrand factor (VWF) through cleavage at a single site in the VWF A2 domain. The precise role that the ADAMTS13 disintegrin-like domain plays in its function remains uncertain. Truncated ADAMTS13 variants suggested the importance of the disintegrin-like domain for both enzyme activity and specificity. Targeted mutagenesis of...
Paper Details
Title
Essential role of the disintegrin-like domain in ADAMTS13 function
Published Date
May 28, 2009
Journal
Volume
113
Issue
22
Pages
5609 - 5616
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