Agonists, but not antagonists, alter the conformation of the hormone-binding domain of androgen receptor.

Published: Feb 1, 1994
Abstract
Androgen receptors synthesized by translation in vitro form dimeric aporeceptor complexes with an androgen response element (ARE). Physiological and synthetic androgens elicit a conformational change in the receptor, which increases the mobility of receptor-ARE complexes in gel retardation assays. Neither a steroidal (cyproterone acetate) nor a non-steroidal (casodex) antiandrogen brings about the same effect and, at high concentrations, reverse...
Paper Details
Title
Agonists, but not antagonists, alter the conformation of the hormone-binding domain of androgen receptor.
Published Date
Feb 1, 1994
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