Targeted photodynamic therapy with multiply-loaded recombinant antibody fragments

Volume: 122, Issue: 5, Pages: 1155 - 1163
Published: Oct 31, 2007
Abstract
Current photodynamic therapy (PDT) of cancer is limited by inefficiencies involved in specifically targeting photosensitizers to tumors. Although antibodies are being explored as targeting vehicles, they present significant challenges, particularly in terms of pharmacokinetics and drug-coupling. We describe here a novel and effective system to covalently attach multiple photosensitizer molecules (both preclinical, pyropheophorbide-a and...
Paper Details
Title
Targeted photodynamic therapy with multiply-loaded recombinant antibody fragments
Published Date
Oct 31, 2007
Volume
122
Issue
5
Pages
1155 - 1163
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