Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells

Volume: 108, Issue: 4, Pages: 1609 - 1614
Published: Jan 25, 2011
Abstract
Radiation therapy can result in bone injury with the development of fractures and often can lead to delayed and nonunion of bone. There is no prevention or treatment for irradiation-induced bone injury. We irradiated the distal half of the mouse left femur to study the mechanism of irradiation-induced bone injury and found that no mesenchymal stem cells (MSCs) were detected in irradiated distal femora or nonirradiated proximal femora. The MSCs...
Paper Details
Title
Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells
Published Date
Jan 25, 2011
Volume
108
Issue
4
Pages
1609 - 1614
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