TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Abstract
In the mammalian central nervous system, slow synaptic excitation involves the activation of metabotropic glutamate receptors (mGluRs). It has been proposed that C1-type transient receptor potential (TRPC1) channels underlie this synaptic excitation, but our analysis of TRPC1-deficient mice does not support this hypothesis. Here, we show unambiguously that it is TRPC3 that is needed for mGluR-dependent synaptic signaling in mouse cerebellar...
Paper Details
Title
TRPC3 Channels Are Required for Synaptic Transmission and Motor Coordination
Published Date
Aug 1, 2008
Journal
Volume
59
Issue
3
Pages
392 - 398
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