CENTRAL CANNABINOID 1 RECEPTOR ANTAGONIST ADMINISTRATION PREVENTS ENDOTOXIC HYPOTENSION AFFECTING NOREPINEPHRINE RELEASE IN THE PREOPTIC ANTERIOR HYPOTHALAMIC AREA

It is widely assumed that LPS lowers arterial pressure during sepsis by stimulating release of TNF-alpha and other vasoactive mediators from macrophages. However, recent data from this and other laboratories have shown that LPS hypotension can be prevented by inhibiting afferent impulse flow in the vagus nerve, by blocking neuronal activity in the nucleus of the solitary tract, or by blocking alpha-adrenergic receptors in the preoptic...