Platelet-rich plasma and chronic wounds: remaining fibronectin may influence matrix remodeling and regeneration success

Background Platelet-rich plasma has been largely used as a therapeutic option for the treatment of chronic wounds of different etiologies. The enhanced regeneration observed after the use of platelet-rich plasma has been systematically attributed to the growth factors that are present inside platelets' granules. Aim We hypothesize that the remaining plasma and platelet-bound fibronectin may act as a further bioactive protein in platelet-rich...