Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Abstract
Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells. Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2), isolated from SARS coronavirus (SARS-CoV)-permissive Vero E6 cells, that efficiently binds the S1 domain of the SARS-CoV S protein. We found that a soluble form of ACE2, but not...
Paper Details
Title
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Published Date
Nov 27, 2003
Journal
Volume
426
Issue
6965
Pages
450 - 454
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