MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2.
Abstract
Ethanol is a tumor promoter and may enhance the metastasis of breast cancer. We have previously demonstrated that over-expression of ErbB2 promoted ethanol-mediated invasion of mammary epithelial cells and breast cancer cells. However, the underlying cellular/molecular mechanisms remain unknown. By gelatin zymography, we showed that over-expression of ErbB2 increased the production of matrix metalloproteinase-2 (MMP-2) and MMP-9 in human mammary...
Paper Details
Title
MMP-2 mediates ethanol-induced invasion of mammary epithelial cells over-expressing ErbB2.
Published Date
Jul 1, 2006
Volume
119
Issue
1
Pages
8 - 16
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