Processable Cyclic Peptide Nanotubes with Tunable Interiors

Published on Sep 14, 2011in Journal of the American Chemical Society14.612
· DOI :10.1021/JA2063082
Rami Hourani10
Estimated H-index: 10
(University of California, Berkeley),
Chen Zhang2
Estimated H-index: 2
(University of California, Berkeley)
+ 5 AuthorsTing Xu39
Estimated H-index: 39
(University of California, Berkeley)
A facile route to generate cyclic peptide nanotubes with tunable interiors is presented. By incorporating 3-amino-2-methylbenzoic acid in the d,l-alternating primary sequence of a cyclic peptide, a functional group can be presented in the interior of the nanotubes without compromising the formation of high aspect ratio nanotubes. The new design of such a cyclic peptide also enables one to modulate the nanotube growth process to be compatible with the polymer processing window without compromising the formation of high aspect ratio nanotubes, thus opening a viable approach toward molecularly defined porous membranes.
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