Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
Abstract
Diffuse-type gastric carcinoma (DGC) is characterized by a highly malignant phenotype with prominent infiltration and stromal induction. We performed whole-exome sequencing on 30 DGC cases and found recurrent RHOA nonsynonymous mutations. With validation sequencing of an additional 57 cases, RHOA mutation was observed in 25.3% (22/87) of DGCs, with mutational hotspots affecting the Tyr42, Arg5 and Gly17 residues in RHOA protein. These positions...
Paper Details
Title
Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma
Published Date
May 11, 2014
Journal
Volume
46
Issue
6
Pages
583 - 587
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