Solid-Phase Synthesis of a 6-Phenylquinolin-2(1H)-one Library Directed toward Nuclear Hormone Receptors
Abstract
A library of 6-phenylquinolin-2(1H)-ones with diversity at position 1 and the ortho, meta, and para positions of the pendant phenyl ring has been synthesized using solid-phase parallel synthetic techniques. A key step in the synthesis of the library is a tandem alkylation cleavage in which diversity can be introduced at position 1 simultaneously to the cleavage from the resin. The yields of this step were significantly improved over what has...
Paper Details
Title
Solid-Phase Synthesis of a 6-Phenylquinolin-2(1H)-one Library Directed toward Nuclear Hormone Receptors
Published Date
May 4, 2005
Volume
7
Issue
4
Pages
567 - 573
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