Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats
Abstract
In our study, we examined anti-ulcerogen and antioxidant effects of dantrolene sodium on ethanol-induced gastric lesions in rats. Dantrolene sodium was administered intraperitoneally (i.p.) in several doses, and famotidine was used at a dose of 20 mg kg (-1). It was found that pretreatment with dantrolene sodium at doses of 1, 5 and 10 mg kg(-1) significantly reduced ethanol-induced gastric damage and malondialdehyde levels, and significantly...
Paper Details
Title
Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats
Published Date
May 1, 2002
Journal
Volume
45
Issue
5
Pages
421 - 425
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