New Isoflavones and Pterocarpane with Hepatoprotective Activity from the Stems ofErycibe expansa

The methanolic extract from the stems of Erycibe expansa was found to show a hepatoprotective effect on D-galactosamine-induced cytotoxicity in primary cultured mouse hepatocytes. By bioassay-guided separation, two new prenylisoflavones and a pterocarpane, erycibenins A (1), B (2), and C (3), were isolated from the active fraction (the EtOAc-soluble fraction) together with ten isoflavones (4 - 13) and seven pterocarpanes (14 - 20). The...