Microdistribution of fluorescently-labeled monoclonal antibody in a peritoneal dissemination model of ovarian cancer
Abstract
The microdistribution of therapeutic monoclonal antibodies within a tumor is important for determining clinical response. Nonuniform microdistribution predicts therapy failure. Herein, we developed a semiquantitative method for measuring microdistribution of an antibody within a tumor using in situ fluorescence microscopy and sought to modulate the microdistribution by altering the route and timing of antibody dosing. The microdistribution of a...
Paper Details
Title
Microdistribution of fluorescently-labeled monoclonal antibody in a peritoneal dissemination model of ovarian cancer
Published Date
Feb 11, 2010
Journal
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Notes
History