The FGFR Landscape in Cancer: Analysis of 4,853 Tumors by Next-Generation Sequencing

Molecular profiling may have prognostic and predictive value, and is increasingly used in the clinical setting. There are more than a dozen fibroblast growth factor receptor (FGFR) inhibitors in development. Optimal therapeutic application of FGFR inhibitors requires knowledge of the rates and types of FGFR aberrations in a variety of cancer types.We analyzed frequencies of FGFR aberrations in 4,853 solid tumors that were, on physician request,...