Effects of toxic cellular stresses and divalent cations on the human P2X7 cell death receptor.

The purpose of this study was to investigate responses to toxic cellular stresses in different human ocular epithelia.Reactivity with a specific anti-P2X7 antibody was studied using confocal fluorescence microscopy on conjunctival, corneal, lens, and retinal cell lines as well as using impression cytology on human ocular cells. Activation of the P2X7 receptor by selective agonists (ATP and benzoylbenzoyl-ATP) and inhibition by antagonists (oATP,...