Deimmunization of Monoclonal Antibodies

Pages: 405 - 423
Published: Dec 10, 2008
Abstract
Immunogenicity is a major limitation to therapy with certain monoclonal antibodies and proteins. A major driver for immunogenicity is the presence of human T-cell epitopes within the protein sequence which can activate helper T-cells resulting in the sustained production of antibodies and neutralization of the therapeutic effect. Deimmunization is a new technology for location and removal of T-cell epitopes through the combined use of...
Paper Details
Title
Deimmunization of Monoclonal Antibodies
Published Date
Dec 10, 2008
Pages
405 - 423
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