Absolute oxygen R_1e imaging in vivo with pulse electron paramagnetic resonance

Tissue oxygen (O2) levels are among the most important and most quantifiable stimuli to which cells and tissues respond through inducible signaling pathways. Tumor O2 levels are major determinants of the response to cancer therapy. Developing more accurate measurements and images of tissue O2 partial pressure (pO2), assumes enormous practical, biological, and medical importance.We present a fundamentally new technique to image pO2 in tumors and...