Tissue-specific differences in inflammatory infiltrate and matrix metalloproteinase expression in adipose tissue and liver of mice with diet-induced obesity

Aim: While low grade inflammation persists in both visceral fat and hepatic tissue in obesity, these changes often result in progressive disease and fibrosis only in the liver and not in adipose tissue. We hypothesized that a tissue‐specific difference in obesity‐induced inflammatory cell infiltrate may be responsible for such organ difference in susceptibility to fibrosis. Methods: Mice were fed either standard chow or a high fat diet over 19...