Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia

Volume: 22, Issue: 3, Pages: 167S - 173S
Published: Sep 1, 2009
Abstract
During dietary deficiency of magnesium neurogenic inflammation is mediated, primarily, by elevated levels of substance P (SP). The enzyme most specific for degrading this neuropeptide is neutral endopeptidase (NEP). In recent studies we found that pharmacological inhibition of NEP by phosphoramidon resulted in elevated plasma levels of SP and greater oxidative stress. We also observed that hypomagnesemia reduced cardiac and intestinal expression...
Paper Details
Title
Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia
Published Date
Sep 1, 2009
Volume
22
Issue
3
Pages
167S - 173S
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.