Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells

Volume: 59, Issue: 4, Pages: 886 - 894
Published: Feb 15, 1999
Abstract
The mammalian target of rapamycin (mTOR) has been shown to link growth factor signaling and posttranscriptional control of translation of proteins that are frequently involved in cell cycle progression. However, the role of this pathway in cell survival has not been demonstrated. Here, we report that rapamycin, a specific inhibitor of mTOR kinase, induces G 1 null cell cycle arrest and apoptosis in two rhabdomyosarcoma cell lines (Rh1 and Rh30)...
Paper Details
Title
Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells
Published Date
Feb 15, 1999
Volume
59
Issue
4
Pages
886 - 894
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