Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Abstract
Tumor relapse after chemotherapy-induced regression is a major clinical problem, because it often involves inoperable metastatic disease. Tumor-associated macrophages (TAM) are known to limit the cytotoxic effects of chemotherapy in preclinical models of cancer. Here, we report that an alternatively activated (M2) subpopulation of TAMs (MRC1(+)TIE2(Hi)CXCR4(Hi)) accumulate around blood vessels in tumors after chemotherapy, where they promote...
Paper Details
Title
Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy
Published Date
Aug 31, 2015
Journal
Volume
75
Issue
17
Pages
3479 - 3491
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