Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development
Volume: 90, Issue: 2, Pages: 177 - 190
Published: Sep 17, 2015
Abstract
The C5a/C5a receptor (C5aR) pathway, a key component in the proinflammatory immune response, is an attractive therapeutic target since its dysregulation is implicated in a variety of autoimmune and inflammatory disorders. The objective of the present study was to validate a receptor occupancy (RO) assay for a human anti‐C5aR monoclonal antibody drug candidate, NNC0215‐0384 (NN0384). This flow cytometry‐based assay measures the percentage (%),...
Paper Details
Title
Validation of a flow cytometry-based assay to assess C5aR receptor occupancy on neutrophils and monocytes for use in drug development
Published Date
Sep 17, 2015
Volume
90
Issue
2
Pages
177 - 190
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