Signature of protein unfolding in chemical exchange saturation transfer imaging
Abstract
Chemical exchange saturation transfer (CEST) allows the detection of metabolites of low concentration in tissue with nearly the sensitivity of MRI with water protons. With this spectroscopic imaging approach, several tissue-specific CEST effects have been observed in vivo. Some of these originate from exchanging sites of proteins, such as backbone amide protons, or from aliphatic protons within the hydrophobic protein core. In this work, we...
Paper Details
Title
Signature of protein unfolding in chemical exchange saturation transfer imaging
Published Date
May 26, 2015
Journal
Volume
28
Issue
7
Pages
906 - 913
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