Re-irradiation of head and neck cancer-impact of total dose on outcome.

Aim: To evaluate the outcome of re-irradiation and to define favourable pre-treatment characteristics. Patients and Methods: seventy-five patients with locally recurrent head and neck cancer were treated with re- irradiation, either postoperatively or as definitive treatment, with and without chemotherapy. Mean time period between first and second series of irradiation was 19 months. Mean overall dose of re-irradiation was 46 Gy. Median...