Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3‐O‐Methyl‐D‐glucose

Purpose To evaluate the feasibility to detect tumors and metastases by the chemical exchange saturation transfer (CEST) MRI technique using 3‐O‐Methyl‐D‐glucose (3OMG), a nonmetabolizable derivative of glucose that is taken up rapidly and preferentially by tumors and is entirely excreted by the kidneys. Methods In vivo CEST MRI experiments were performed on a Bruker 7 Tesla Biospec on implanted orthotopic mammary tumors of mice before and...