Differential responses of human monocytes and macrophages to IL-4 and IL-13
Abstract
The primary interleukin-4 (IL-4) receptor complex on monocytes (type I IL-4 receptor) includes the 140-kDa α chain (IL-4Rα) and the IL-2 receptor γ chain, γc, which heterodimerize for intracellular signaling, resulting in suppression of lipopolysaccharide (LPS)-inducible inflammatory mediator production. The activity of IL-13 on human monocytes is very similar to that of IL-4 because the predominant signaling chain (IL-4Rα) is common to both...
Paper Details
Title
Differential responses of human monocytes and macrophages to IL-4 and IL-13
Published Date
Oct 1, 1999
Journal
Volume
66
Issue
4
Pages
575 - 578
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