Survival versus apoptotic 17β‐estradiol effect: Role of ERα and ERβ activated non‐genomic signaling

The capability of 17β‐estradiol (E2) to induce the non‐genomic activities of its receptors (ERα and ERβ) and to evoke different signaling pathways committed to the regulation of cell proliferation has been analyzed in different cell cancer lines containing transfected (HeLa) or endogenous (HepG2, DLD1) ERα or ERβ. In these cell lines, E2 induced different effects on cell growth/apoptosis in dependence of ER isoforms present. The E2–ERα complex...