Glycated Collagen Induces α11 Integrin Expression Through TGF‐β2 and Smad3
Abstract
The adhesion of cardiac fibroblasts to the glycated collagen interstitium in diabetics is associated with de novo expression of the α11 integrin, myofibroblast formation and cardiac fibrosis. We examined how methylglyoxal-glycated collagen regulates α11 integrin expression. In cardiac fibroblasts plated on glycated collagen but not glycated fibronectin, there was markedly increased α11 integrin and α-smooth muscle actin expression. Compared with...
Paper Details
Title
Glycated Collagen Induces α11 Integrin Expression Through TGF‐β2 and Smad3
Published Date
Oct 28, 2014
Volume
230
Issue
2
Pages
327 - 336
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