Time course of lesion development in the hairless guinea-pig model of sulfur mustard-induced dermal injury

The objective of these studies was to provide detailed analyses of the time course of sulfur mustard (SM) vapor‐induced clinical, histological, and biochemical changes following cutaneous exposure in hairless guinea‐pigs. Three 6 cm 2 sites on the backs of each guinea‐pig were exposed to SM vapor (314 mg 3 ) for 6 minutes (low dose) or 12 minutes (high dose). Animals were killed at 6, 24, and 48 hours, or 2 weeks postexposure. Erythema, edema,...