Cooperative role of tumour necrosis factor‐α, interleukin‐1β and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice
Abstract
BACKGROUND AND PURPOSE; Chronic joint inflammation and pain are the hallmarks of disease in patients with inflammatory arthritis, notably rheumatoid arthritis. The aim of the present study was to investigate the relative contribution of tumour necrosis factor (TNF)-α, interleukin (IL)-1β and neutrophil influx for joint inflammation and nociception in a novel murine model of antigen-induced arthritis (AIA).AIA was induced by administration of...
Paper Details
Title
Cooperative role of tumour necrosis factor‐α, interleukin‐1β and neutrophils in a novel behavioural model that concomitantly demonstrates articular inflammation and hypernociception in mice
Published Date
Dec 6, 2010
Volume
162
Issue
1
Pages
72 - 83
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