A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain
Abstract
Cancer pain is a debilitating disorder and a primary determinant of the poor quality of life. Here, we report a non-vascular role for ligands of the Vascular Endothelial Growth Factor (VEGF) family in cancer pain. Tumor-derived VEGF-A, PLGF-2, and VEGF-B augment pain sensitivity through selective activation of VEGF receptor 1 (VEGFR1) expressed in sensory neurons in human cancer and mouse models. Sensory-neuron-specific genetic...
Paper Details
Title
A Functional Role for VEGFR1 Expressed in Peripheral Sensory Neurons in Cancer Pain
Published Date
Jun 1, 2015
Journal
Volume
27
Issue
6
Pages
780 - 796
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