Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress
Abstract
The TET enzymes convert methylcytosine to the newly discovered base hydroxymethylcytosine. While recent reports suggest that TETs may play a role in response to oxidative stress, this role remains uncertain, and results lack in vivo models. Here we show a global decrease of hydroxymethylcytosine in cells treated with buthionine sulfoximine, and in mice depleted for the major antioxidant enzymes GPx1 and 2. Furthermore, genome-wide profiling...
Paper Details
Title
Genome-wide hydroxymethylcytosine pattern changes in response to oxidative stress
Published Date
Aug 4, 2015
Journal
Volume
5
Issue
1
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