Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Abstract
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock. How caspase-11 executes these downstream signalling events is largely unknown. Here we show that gasdermin D is essential for caspase-11-dependent pyroptosis and...
Paper Details
Title
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Published Date
Oct 29, 2015
Journal
Volume
526
Issue
7575
Pages
666 - 671
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